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Heitmar, R., Brown, J., & Kyrou, I

defined primary cerebral folate deficiency as a neurological syndrome associated with normal levels of extraneurological folate but reduced levels of 5-methyltetrahydrofolate (5MTHF), a folate metabolite in cerebrospinal fluid [101]

Cellular Health: Investigation into overall cellular function and maintenance

Toxics 12:395

Some of these commenters asserted that the imposition of an impossible requirement is, by definition, arbitrary and capricious and cited case law to support this belief