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This process requires the following two enzymes: glutamyl cysteine synthetase and glutathione synthetase

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Glutathione supplements cannot enter cells as there is an insurmountable concentration gradient across the cell membrane and, although there are well-understood membrane transporters for transporting glutathione from the inside to the outside of the cell, therefore most cell types, there are no transporters for transporting extracellular glutathione in the reverse direction i.e

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