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Activated macrophages are generally categorized into two kinds: M1 macrophages, which participate in pro-inflammatory responses, and M2 macrophages, which engage in anti-inflammatory responses (84)

The latter is considered to be the rate-controlling enzyme for the catabolic conversion of hepatic cholesterol to bile acids for subsequent elimination in the feces

Nrf2 promotes -glutamyl-peptide (GC) synthesis and inhibits ferroptosis caused by Cys 2 deficiency by regulating the catalytic subunit of glutamate-cysteine ligase (GCLC) [89]

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Because homocysteine is an excitatory amino acid, it activates metabotropic glutamate receptors (mGluRs) and NMDA receptors, causing increased glutamatergic neurotransmission

For local delivery systems, most current studies rely on static culture or shortterm animal models, which fail to adequately recapitulate the complex physiological conditions characterized by the coexistence of gingival crevicular fluid flow and enzymatic degradation