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No human clinical trials have been completed

For instance, in one 1960s study of intravenous NAD+ for addiction, patients who received a fast IV drip experienced immediate headache and shortness of breath, whereas those given the same dose at a slower drip rate (under approximately 35 drops/min) had no distress

B12 deficiency is more common than you might think

[1] [2] Injecting cold medication directly from the refrigerator may increase the likelihood of injection site reactions

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This may occur in patients even without evidence of adrenal insufficiency