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Collectively, these findings suggest that disease-associated mutations, though mechanistically diverse, converge in their impact on astrocytic reactivity by resetting the threshold at which astrocytes enter reactive states

Circadian desynchronization triggers premature cellular aging in a diurnal rodent

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Update of the Hyper-CVAD and Imatinib Mesylate Regimen in Philadelphia (Ph) Positive Acute Lymphocytic Leukemia (ALL)

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It may be that there are general dietary (precursor amino acids and purines are both high in many foods), hydration, hepatic, or other influences that affect purines and indoleamines and TYR similarly