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Their resistance has been linked to their capacity to reduce ROS levels through the accumulation of intracellular antioxidants like glutathione and the induction of GCL, as demonstrated in breast and liver TICs [18,19,20]

References Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA (2022) Declining muscle NAD(+) in a hyperandrogenism PCOS mouse model: possible role in metabolic dysregulation

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Similarly, high intake of refined grains in rats has been shown to elevate MDA levels and reduce GSH, thereby increasing oxidative stress and promoting lipid peroxidation

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