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Description

The liver uses this same system in bile acid synthesis and the hydroxylation of cholecalciferol to 25-hydroxycholecalciferol (vitamin D3;), and the kidney uses it to hydroxylate vitamin D3 to its biologically active 1,25-dihydroxylated form

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All steps in these machineries are evolutionarily conserved from yeast to man

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, 1992), and neurodevelopment (Truman et al

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Some neonatal studies show no depletion at therapeutic doses, suggesting babies may metabolize it differently

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