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10.2147/IJN.S132472 168

Native IGF-1 has a very short half-life of about 10 minutes due to rapid clearance and breakdown

Gorbatyuk M, Sinha NR, Kumar R, Zhylkibayev A, Athar M, McNutt P, Mohan RR

10.1126/scitranslmed.3009885 46

Invertebrates possess many types of neuroglial cells that create brainbody barriers, protect and support axons, and produce complex defensive responses to external insults

These findings lend support to the hypothesis that high levels of oxidative stress may contribute to the pathophysiology of depressionthough its effects may be anatomically selective