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The degeneration of the intervertebral disc is characterized by a decrease in the number of viable cells, especially the number of nucleus pulposus cells, and the decline of their function, resulting in the loss of extracellular matrix (ECM), especially proteoglycans 8

Fangming Chen, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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