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Another clinical trial (NCT00395655) reported the utilization of demethylating agent hydralazine along with valproic acid plus neoadjuvant cyclophosphamide and doxorubicin therapy in locally advanced breast cancer patients

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Loss of DNA methylation in the CDH3 gene promoter results in the overexpression of P-cadherin in colorectal and breast carcinomas, which decreased cell polarity and promotes the invasion and migration of colorectal and breast cancer cells (Paredes et al., 2005

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The intestine facilitates material exchange with luminal contents through specialized pathwaysnotably the paracellular pathway, which typically permits the passage of molecules larger than 15 (approximately 3.5 kDa) (51)