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Despite these advances, most studies are still in preclinical stages, highlighting the need for rigorous human trials to validate the safety and efficacy of hydrogel DDS

In animal experiments, increases in VEGF were observed at both 2 h and 1 month following TBI, indicating impaired vascularity in both the short and long term (120, 121)

Current clinical advancement strategies include structural engineering of vitamin K analogs (e.g., C11-alkyl chain-modified MK4-C11) to enhance brain bioavailability and adeno-associated virus (AAV)-mediated FSP1 gene delivery (NCT05543659) to restore vitamin K reduction capacity, driving the transformation of vitamin K from a fundamental nutrient into a clinically viable targeted ferroptosis therapeutic

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doi: 10.1681/ASN.2018010039 229 TangSXiaoX

Among the peptides in this article, it has some of the more credible evidence, particularly for skin health