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Description

NAD+ plays crucial roles in maintaining genomic stability through its function as a substrate for poly(ADP-ribose) polymerases (PARPs), a family of enzymes that detect and respond to DNA damage by catalyzing the synthesis of poly(ADP-ribose) polymers from NAD+

Moreover, triterpenoids from SBT displayed inhibitory effects on nitric oxide production and enhanced radical-scavenging activities, indicating their potential as antioxidants (154)

To mitigate translational risk, phase 0 microdosing studies using 89 Zr-labeled nanoparticles are proposed to assess human biodistribution prior to efficacy trials [225]