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Non-alcoholic fatty liver disease - a global public health perspective

These include: 2-hydroxybutyric acid, linked to oxidative stress and insulin resistance Methylsuccinic, tricarballylic, and orotic acids, often tied to microbial imbalance or urea cycle problems Various keto and hydroxy acids such as 2-oxo-4-methiolbutyric acid, 3-methylglutaric acid, and 3-oxoglutaric acid, which may reflect sulfur metabolism, mitochondrial overload, or B-vitamin deficiency When interpreted in context, these markers help identify blocks or imbalances in methylation-related pathways

Rivard, R

In overweight/obese PCOS women with vitamin D deficiency, daily administration of 1,000 mg of calcium combined with 50,000 IU of vitamin D weekly for 8 weeks revealed that calcium supplementation, with or without additional vitamin D, resulted in significant diminutions in FBG, FINS, HOMA-IR, TG, and VLDL-C, along with a notable increase in the QUICKI (117)

Neurotoxicology 20 , 379397 (1999)