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Volcano plot screening showed that the ribosomal protein RPL15 significantly decreased after GGT knockout

Science 379 , 10231030 (2023)

The addition of a C-terminal Pro-Gly-Pro extension to the tuftsin core dramatically improved metabolic stability, allowing the peptide to survive intranasal delivery long enough to exert meaningful neurobiological effects

A comparison of activities revealed that compound 3f was significantly more active than the latter two mentioned above

Further emphasizing their role as signaling molecules, ROS and particularly H 2 O 2 , are also major regulators of gene expression, as evidenced by extensive genome expression reprogramming under conditions promoting H 2 O 2 accumulation (Queval et al., 2007