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WES and/or WGS studies had not distinguished between smoking and non-smoking individuals until 2021, when results emerged from the two formerly discussed somatic alteration profiling studies of never-smoking LUAD, which included data from matched non-malignant tissue analyses ,7,78

In clinical trials like SURMOUNT-1, approximately 6% to 7% of patients reported constipation, but in real-world clinical practice, we see this number much higher

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