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It's the gap between aligning a peptide protocol with the biology it was designed to exploit versus forcing it to work against circadian receptor rhythms that have been conserved across 200 million years of mammalian evolution

( a ) Flowchart of the Tn-seq experiment

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Deviation of the observed pathway score from the null distribution was quantified by the fraction of times that the simulated score was more extreme than the observed score

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Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids