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Sureda A, Pons A

PIN1 inhibitors synergize with CDK4 inhibitors against TNBC in human cells and immune-compromised mouse models Selective CDK4/6 inhibitors have emerged as effective ER + BC treatment but only have limited efficacy in TNBC, in which RB gene loss occurs predominantly 48,49

Dis Model Mech 8 , 487499, (2015)

Conclusion More and more there is a look at natural elements that, until some time ago, were not given due attention

Blood NADs and Glutathione Metabolites are Perturbed in Various Diseases To explore whether the redox pools were modified by chronic age-related diseases, we examined blood NAD and glutathione metabolites across 11 different diseases, including various cancer types, diabetes (Type II) and neurodegenerative diseases (Parkinsons and Alzheimers)

A positive proliferative response was defined as an SI greater than 5 with p value less than 0.05