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In order to maintain the osteogenic differentiation ability of MSCs, RNA modification, long non-coding RNA regulation, and DNA damage repair are particularly important

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In fact, hypoxia and hypoglycaemia lead to an alteration of the metabolism of the nerve cell, to the extent of depleting (exhausting) the energy reserves (basically, the ATP) and causing the malfunctioning of the mitochondria, with the disorder of the cytochromes and the partial reduction of oxygen

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For nanomedicine, these agencies require comprehensive evaluations of safety, quality, and efficacy, including preclinical studies, pharmacokinetic analyses, and large-scale clinical trials