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Annals of dermatology

The expression of both circFNDC3B and SLC7A11 is enhanced in clinical OSCC tissues, whereas the expression of miR-520d-5p is reduced, and the silencing of circFNDC3B inhibits tumor growth in vivo (Yang et al., 2021)

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By blocking this pathway, GPS can reduce the expression of fibrotic genes and collagen production, thereby mitigating liver fibrosis

It is well established that calcitriol, after forming a complex with its receptor, vitamin D receptor (VDR) and heterodimerizing with the retinoic acid receptor (RXR), directly inhibits preproPTH gene transcription by binding to a specific DNA response element (VDRE) located in the 5-flanking region of the gene

These findings underscore the therapeutic potential of targeting mitochondrial metabolism in the OXPHOS-driven mitochondrial subtype GBMs, a strategy that may differ from interventions aimed at glycolytic-dominant subtypes of GBM