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Using structure-based analyses and cell models, including patient fibroblasts, of this variant, we found that the missense variant destabilized a critical loop, which disrupted the active site and caused a substantial loss of enzymatic function

A number of plants, such as Senecio salignus, Chenopodium ambrosioides L., and Cannabis sativa L., contain caryophyllene oxide, a natural bicyclic sesquiterpene that possesses significant anti-HCC activities by promoting ferritinophagy and ferroptosis (122)

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Knockdown of GCKR increased glycogen content GCKR P446L significantly increased protein levels of GYS2, FASN, ACC and GCK