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The cysteine S -conjugates produced in the tubules (and S -conjugates arising from tissues other than the kidney reaching the tubular lumen via glomerular filtration) may be transported into the renal epithelial cells from the glomerular filtrate by active and passive uptake mechanisms (Anders, 2004)

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One biotype of depression, for example, is marked by an inability to eliminate excess copper

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Using that approach, the current picture is fairly clear