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MaxQuant was set to search with the following parameters: peptide tolerance at 10 ppm, MS/MS tolerance at 0.02 Da, carbamidomethyl (C) as a fixed modification, oxidation (M) as a variable modification, and a maximum of two missed cleavages

However, in the context of chronic bleeding and potential macrophage dysfunction, the release of iron can overwhelm normal storage and handling mechanisms, leading to iron overload [24]

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The expansion of global biologics pipelines, especially monoclonal antibodies, bispecifics, and Fc-fusion proteins, is creating sustained demand for scalable, high-performance affinity resins