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Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

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These classifications are not based on the severity of disease, although certain phenotypes may correlate with increased risk for more severe disease

reported that higher melatonin metabolite concentrations (urinary 6-sulfatoxymelatonin: UME) are associated with significantly lower cognitive performance in the MMSE ( n = 935) and in the Geriatric Depression Scale ( n = 1,097) [259]

215 The gut microbiome plays a critical role in regulating gut-brain communication by producing chemicals that modify hormone and neurotransmitter release, and possibly induce epigenetic changes (changes in DNA structure that impact gene expression) in the central nervous system