10.1097/01.pgp.0000236951.33914.1b Int
However, the authors acknowledge the possibility of a treatment bias in the sickest of patients
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Although the ADI route is somehow similar to an inverted urea cycle, from an evolutionary view point these pathways are not related at all (Liu et al., Acid and amino acid decarboxylations Apart from its secondary involvement in pH buffering, the arginine deiminase route is chiefly an ATP generating pathway useful to complement substrate level phosphorylation
the one or more cofactors or precursors thereof is selected from nicotinamide adenine dinucleotide, Flavin adenine dinucleotide (FADH 2 ), Flavin adenine dinucleotide phosphate, alpha-lipoic acid, acetyl-l-carnitine, niacinamide (vitamin B3), nicotinamide adenine dinucleotide phosphate (NADPH), thiamine, riboflavin, niacin, pyridoxine, cyanocobalamin, biotin, folic acid, pantothenic acid, vitamin C, thiamine pyrophosphate, flavin mononucleotide, pyridoxal phosphate, doexyadenoxylcobalamin, methylcobalamin, tetrahydrofolate, and coenzyme A
