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Monoamine oxidase inhibitor drugs (MAOIs) may be used in the treatment of certain depressive disorders

Data from human and animal studies provide strong evidence of neurovascular unit dysfunction with BBB hyperpermeability in association with oxidative stress and neuroinflammation (118), which can increase the susceptibility to neurological disorders such as depression

2024;13(9):e7207

First, a precursor (3-methyl-2-hexenoyl-CoA) is hydrolysed to form 3-methyl-2-hexenol, which is then converted to a glutathione conjugate by the enzyme glutathione- S -transferase

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2 Mechanisms of chemoresistance for GC manuscript formatting 2.1 Drug efflux The intracellular concentration of antitumor drugs needs to remain within the effective concentration range to exert therapeutic effects