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The efficiency of transduced iSPNs was 44.5% for the scrambled shRNA and 47% for the Gsto2 -shRNA-injected mice

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Further, interleukin-4 (IL-4), which induces HIF-2 stabilization in macrophages (Takeda et al., 2010), also contributes to HIF-2 accumulation in activated CD8+ T cells, while IL-2 conditions favor HIF-1 accumulation (Doedens et al., 2013)

Lv C, Ma X, Liang C, Chen Y, Qin F, Zhou C, Huang W, Liu Q, Wang Y, Liu Z, Sun C, Li T, Hou L (2023) The interaction of pterostilbene with Kelch-like ECH-associated protein 1 and its regulation on the nuclear factor erythroid 2-related factor 2/antioxidant response element pathway