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When excessive glutamate is released from the presynaptic, it stimulates the postsynaptic ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs)

Auditors verify clinical indication (ICD-10), stress method, radiotracer details, imaging phases (rest + stress), timing, and the final physician interpretation/report aligned with Centers for Medicare & Medicaid Services guidelines

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Furthermore, in the studies covering a stimulus and disease with organ-specific cytotoxicity, the significance of measuring organ-specific biomarkers greatly increases (Tajima et al., 2019

Neurotrophic agents such as nerve growth factor and brain-derived neurotrophic factor have received research attention concerning their potential to treat AD but have not progressed to clinical trials due to their reasonably large size, inability to penetrate the blood-brain barrier (BBB), and the high cost of synthesis

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