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Second, it argues against a pure placebo effect, because placebo responses tend to diminish more gradually

Slow-healing wounds the original clinical indication

Wasko R, Jaskula M, Kotwicka M, Andrusiewicz M, Jankowska A, Liebert W, et al

Methadone continuation : This is more nuanced

Pain Research and Management , 2018, 6358624

Benzyl alcohol at 0.9% concentration is bacteriostatic rather than bactericidal, which is sufficient to maintain sterility in a sealed vial environment during the research window.