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For example, Shikonin, a natural naphthoquinone isolated from the roots of Lithospermum erythrorhizon , can induce apoptosis and necrotic of GBM cells (35) by inhibiting EGFR phosphorylation and decreasing phosphorylation of EGFR downstream molecules, including AKT, P44/42MAPK and PLC1

Improved hemophagocytic lymphohistiocytosis index predicts prognosis of adult Epstein-Barr virus-associated HLH patients

Pharmacokinetics in mice BALB/c nude mice (4-week-old) were purchased from the Chinese Academy of Science, and all procedures for the in vivo nude mice study were approved by the Animal Care Committee of Chongqing Medical University

CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys

Neurobiol Stress 9:921

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