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Apocynin is a bioactive phenol extracted from the roots of Apocynum venetum L., and as a NOX2 inhibitor, it can prevent ROS production and reduce inflammatory responses (Philippens et al., 2013)

The incubation of vonifimod with human hepatocytes resulted in the formation of nine metabolites, including hydroxy-vonifimod (M1 and M2), inactive carboxylic acids (M3 M6), active vonifimod-phosphate (M7), and M3 glucuronides (M3-G1 and M3-G2)

Mitchell CJ, Churchward-Venne TA, Parise G, Bellamy L, Baker SK, Smith K, Atherton PJ, Phillips SM

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Type 1 is the isoform primarily responsible for DHT production in the scalp, making this a targeted effect where it matters most