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However, limitations of this pioneering study include the need to use heteroatom-rich amino linkers and the fact that only nucleophilic substitution reactions work well with thalidomide derivatives, making one-pot synthesis difficult to use with other types of cereblon ligands 177

In line with that, hematopoietic stem cells mature and hematopoietic tissue decreases, resulting in a mitigated lymphocyte production [12, 13]

Meanwhile, NETs in the portal zone bind to fibronectin via 41 integrin, forming a three-dimensional scaffold that directs the extension of regenerating vessels (138).Metabolic reprogramming studies show that succinate released by portal zone NETs induces enhanced glycolysis in bile duct cells via the SUCNR1-GPR91 signaling axis, providing energy support for bile duct regeneration (139, 140)

ZH wrote the first draft of the manuscript

10.1023/A:1005390105171

Stepens A, Logina I, Liguts V, Aldi P, Ekteina I, Platkjis A, et al