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High expression of claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5

There were both prophylactic and therapy effects

It can be linked with: Pregnancy Lack of exercise A sudden change in diet A diet with not enough fibre Having to stay in bed for a long time Medicines such as morphine or codeine Loss of 'tone' of the bowel muscles in older people Whatever the cause, constipation can be uncomfortable

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National Institute of Diabetes and Digestive and Kidney Diseases