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Makarova, K.S., Aravind, L., Wolf, Y.I

GHS can mildly increase insulin resistance and glycated hemoglobin (HbA1c) levels over time

GH Axis Integrity Assessment Tesamorelin stimulation testing is used in pre-clinical research to assess somatotroph secretory reserve characterising peak GH responses as a functional readout of pituitary GH axis integrity across disease models, ageing paradigms, and pharmacological intervention studies

When used together, these compounds support increased GH and IGF-1 levels through complementary pathways, resulting in a more sustained and efficient hormonal response