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doi:10.1093/toxsci/kfm165

Moreover, inhibition of GS activity in TAMs induces the polarization of M2-type TAMs toward the M1 type, accompanied by a decrease in glutamine levels and increase of succinic acid and accumulation of HIF-1

On the other hand, seborrhea, acne, T2D and cancer are frequently observed in acromegaly with increased GH/IGF-1 signaling in comparison to healthy controls [16]