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Disadvantages are: not FDA-approved for women, reversibly raising liver tests (need to monitor every 3 months)

Targeting VEGF has dramatically improved the management of many diseases like blinding eye diseases such as age-related macular degeneration and diabetic and hypertensive retinopathy and shows promising data in cancer treatment [11]

PMC 6522259

They are produced in a separate peer-reviewed procedure at IPCS

In addition, PGA and Kyn/Trp may have potential as biomarkers for disease monitoring and risk stratification, although their clinical utility will require validation in independent and longitudinal cohorts

Based on these findings, the authors concluded that assessment of liver enzymes could identify individuals at a high risk of incident T2D who may benefit from T2D prevention interventions