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These fractions contain heterogeneous plasma-membrane microdomains that are enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol-anchored proteins, as well as several membrane-associated signalling molecules, such as LYN

10.1016/j.cmet.2015.04.016 Cell

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Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells

In human AML stem cells, BCAT1 is overexpressed, and the BCAA pathway is activated by the low levels of -KG, displaying a DNA hypermethylation phenotype similar to IDH mutant-positive cancers (Raffel et al., 2017)