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The study had a response rate of 77% in patients with alopecia areata, and even saw some benefit in patients suffering from alopecia totalis and universalis

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182,183 Moreover, physcion and its derivative S3, novel small-molecule PGD inhibitors which fits in a pocket of PGD near the binding site of 6-PG to inhibit PGD enzyme activity and then decrease the NADPH level, exhibit excellent anticancer effects and sensitize leukemia cells to antimalarial agent dihydroartemisinin (DHA)

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[11] Liver Repair and Regeneration: Milk thistle has been shown to support the regeneration of liver cells

As previously established, the liver relies heavily on glutathione conjugation (via Glutathione S-Transferases) to neutralize and excrete toxic intermediates, including excess inflammatory mediators and circulating histamine