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Conditions associated with elevated B12 levels include: Liver disease : Hepatocellular damage releases stored B12 into circulation, with levels correlating with disease severity in conditions such as cirrhosis, hepatitis, and hepatocellular carcinoma Renal impairment : Reduced kidney function decreases B12 clearance, leading to accumulation Haematological malignancies : Myeloproliferative disorders, acute leukaemia, and polycythaemia vera can elevate B12 through increased production of B12-binding proteins (transcobalamins) Solid tumours : Certain cancers, particularly those affecting the liver or gastrointestinal tract, may elevate B12 levels A specific concern relates to cyanocobalamin in patients with Leber's hereditary optic neuropathy , a rare mitochondrial disorder

When platelet levels drop, doctors may investigate possible medical causes and recommend nutritional or medical treatment

But no substantial studies have shown a direct effect of vitamin B12 on human weight loss efforts

Can Genetics and Lifestyle Both Cause Dark Circles

Neurological consequences of obesity

Elle entre dans le plasma sous forme de mthylcobalamine et saccumule en rserve dans le foie sous forme de dsoxyadnosylcobalamine