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The accumulation of ROS has been demonstrated to trigger the phosphorylation and activation of the key kinase p38 MAPK, suggesting that ROS is a potential activator of the MAPK signaling pathway [75]

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The local production of IGF-1 is controlled primarily by GH and other hormones (e.g., parathyroid and thyroid hormones) (Bikle et al., 2009)

Another difference to be considered between our two cell models is the number of donors

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Hinokitiol is capable to alleviate excessive glutamate to induce ROS, lipid peroxidation, and Fe 2+ accumulation in neuronal cells and relieve brain tissue damage (Tang et al., 2023)