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The GHIGF1 axis and longevity

Oral BPC-157 works for gut health applications but delivers lower bioavailability for joint and tendon targets

Together with the absence of symptoms associated with IGF-1-mediated effects such as fluid retention, tissue edema, or impaired glucose tolerance, these results demonstrate that AOD-9604 does not activate the growth hormone/IGF-1 pathway and therefore functions through an entirely appetite-independent mechanism

Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress

124,125 In a randomized placebo-controlled trial in 52 participants with menopausal symptoms, 30 mg vitex extract twice daily for eight weeks reduced hot flashes, anxiety, and total menopausal symptom scores

Fer-1 also down-regulated the expression of adhesion molecules and up-regulated eNOS expression (Figure 1)