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Several approaches may be considered in developing drugs for reversing aberrant DNA methylation like inhibition of the universal methyl group donor SAM, downregulation of methyl-CpG binding domain (MBD) proteins and inhibition of DNMT enzymes (3538)

10.1016/j.psj.2021.101622 86

Aberrant activation of specific transcriptional programs has the capacity to greatly alter cellular state, driving oncogenesis and supporting cancer cell proliferation

Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, et al

This holistic approach also considers factors such as your posture, stress levels, and overall health

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