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Edited by: Bertrand Joseph Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

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4 Discussion This study presents the impact of hepatocyte metabolic zonation on the dynamics of dose-dependent APAP-induced hepatocellular injury at the lobular level through the use of in silico multiscale modeling

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Neurology 67:125130 Cohen I, Todd RD, Harmon S, OMalley KL (1992) Photoreceptors of mouse retinas possess D4 receptors coupled to adenylate cyclase

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Rather surprisingly, this suggests that the benefits of reduced mTORC1 signaling, and increased autophagy may be mediated primarily by an A-independent mechanism and moreover, previous studies have demonstrated that mTORC1 inhibition leads to the suppression of tauopathy 65,66

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The upstream regulatory network is also not fully defined

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