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doi: 10.1371/journal.pone.0037241 168 AdamsLALympJFSt SauverJSandersonSOLindorKDFeldsteinAet al

Although the steric hindrance of amino is small, the bond length of Cu 2+ /amino coordination is longer than that of Cu 2+ /imidazolyl coordination, resulting in the worse stability of Structure B

Although all these strategies converge on exerting anti-inflammatory and antioxidant effects via Nrf2-dependent signaling cascades, they exhibit distinct characteristics and confront unique challenges