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HIF-1 is also known to promote mitochondrial-selective autophagy and thus lower the mitochondrial mass, which suppresses the oxidation of both glucose and fatty acids and decreases mitochondrial ROS production under hypoxic conditions (63)

should be balanced

Sun Y, Han XD, Liu XD

Molecules 23 , 1308 (2018)

Although numerous nanocarriers have been developed for accurate tumor targeting, their limited water solubility makes their stable storage challenging, and poses biosafety risks in clinical translation