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When mitochondrial respiration is impaired in T cells, a metabolic shift toward glycolysis occurs, accompanied by accumulation of tricarboxylic acid cycle intermediates such as succinate

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Funding This work was supported by National Institutes of Health Grants NIEHS R01 ES024756 (to EL), R01 ES031282 (to EL), R01 ES010563 (to MA), and NIMHD U54 MD007582