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Clinically, it presents with severe and persistent retrosternal pain that is not fully relieved by nitrate medications or rest

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107 elaborated on the critical role of skin-on-a-chip in modeling dynamic skin changes, particularly in drug screening and physiological studies

Furthermore, studies have suggested that the therapeutic synergy between sitagliptin and metformin co-administration can increase mRNA and protein expression levels (Daneshjou et al., 2022)