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However, it is necessary to consider that the introduction of a new amide bond increases the susceptibility to hydrolysis and the topological polar surface area (TPSA), as well as contributing to the increase of hydrogen bond donor (HBD) or hydrogen bond acceptor (HBA) count

Guan C, Ji J, Jia C, Guan W, Li X, Jin C, Wang G (2015) A GSHS-like gene from Lycium chinense may be regulated by cadmium-induced endogenous salicylic acid and overexpression of this gene enhances tolerance to cadmium stress in Arabidopsis