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These pathways can be studied in laboratory or preclinical models without automatically proving a treatment effect in humans

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NNMT is an enzyme that catalyzes the methylation of nicotinamide (a NAD+ precursor) and other substrates, using SAM (S-adenosylmethionine) as the methyl donor

Non-B12 causes of persistent symptoms with a high result When symptoms persist and the B12 is high, the symptoms may have nothing to do with B12 at all

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What it does not do, in the published animal data, is push the growth-hormone side of the molecule