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Metabolite signature associated with stress susceptibility in socially defeated mice

Generally, glutamine can be converted in the mitochondria to supplement the tricarboxylic acid (TCA) cycle, or it can be completely oxidized to produce ATP

Despite that mitochondria are exposed to the generation of oxidant species, the existence of an efficient antioxidant defense system, of which mGSH is a critical component, prevents or repairs oxidative damage generated during normal aerobic metabolism (Mari et al., 2013)

The effects of N-acetylcysteine on ovulation and sex hormones profile in women with polycystic ovary syndrome: a systematic review and meta-analysis

1B), and then maintained for 5 days in OL differentiation medium (DM) containing DMEM (Thermo Fisher), 1% P/S (Thermo Fisher), 1 mM sodium pyruvate (Sigma), 0.1% bovine serum albumin (Sigma), 50 g/ml apotransferrin (Sigma-Aldrich), 5 g/ml insulin (Sigma-Aldrich), 30 nM sodium selenite (Sigma), 10 nM biotin (Sigma-Aldrich), 10 nM hydrocortisone (Sigma-Aldrich a), 15 nM triiodothyronine (Sigma), 10 ng/ml ciliary neurotrophic factor (Cell Guidance Systems), and 5 g/ml N-acetyl-cysteine (Sigma-Aldrich)

Glutathione is naturally produced by the liver and plays a crucial role in detoxification, immune function and skin health