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In murine MTB -challenge experiments, metE provided protection when administered as a recombinant protein formulated with either AS01 or AddaS03 adjuvants, with each formulation inducing distinct immune responses

After incubation for 1 h, the DCFH-DA probe (10 M) was added and incubated in the dark for 30 min to detect ROS

Gastrointestinal dysmotility and/or diarrhoea occurs after the acute phase of CDI, but persistent gastrointestinal dysfunction post-infection supports contributions of neuroplasticity in the enteric nervous system (ENS), which has a key role in regulating intestinal motility and secretion, in the natural course of CDI

While each component has demonstrated promise in preclinical research, the evidence base for the combined effect of these peptides remains early-stage